| WR Johnny Wilson - Concussion, Full Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
LB Mohamoud Diabate - Hip, IR. Injured Reserve. Expected Return - Week 6 |
| LB Nakobe Dean - Ankle, Limited Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
G Zak Zinter - Knee, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
| WR DeVonta Smith - Concussion, Full Practice on Wednesday. Questionable for Week 6 vs. Cleveland |
OT Jedrick Wills - Knee, Questionable for Week 6 at Philadelphia |
| WR Britain Covey - Shoulder, IR. Injured Reserve. Expected Return - Week 9 |
RB Pierre Strong Jr. - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
| OT Le'Raven Clark - Undisclosed, IR. Injured Reserve |
DT Maurice Hurst - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
| CB James Bradberry - Lower Leg, IR. Injured Reserve. Expected Return - Week 6 |
SAF Grant Delpit - Concussion, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
| TE Albert Okwuegbunam - Abdomen, IR. Injured Reserve. Expected Return - Week 6 |
LS Charley Hughlett - Ribs, IR. Injured Reserve. Expected Return - Week 11 |
| SAF Sydney Brown - Knee - ACL, Physically Unable to Perform. Expected Return - Week 6 |
RB D'Onta Foreman - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
| WR Ainias Smith - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
DE Myles Garrett - Achilles, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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SAF Ronnie Hickman - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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OT James Hudson - Shoulder, Questionable for Week 6 at Philadelphia |
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MLB Jordan Hicks - Elbow, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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OT Jack Conklin - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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TE David Njoku - Knee, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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C Ethan Pocic - Knee, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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CB Denzel Ward - Hamstring, Did Not Practice on Wednesday. Questionable for Week 6 at Philadelphia |
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DE Alex Wright - Triceps, IR. Injured Reserve |
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RB Nyheim Hines - Knee - ACL, NFI-R for Week 6 at Philadelphia |
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RB Nick Chubb - Knee - ACL + MCL, Physically Unable to Perform. Expected Return - Week 6 |
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OG Wyatt Teller - Knee - MCL, IR. Injured Reserve. Expected Return - Week 8 |
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LB Brandon Bouyer-Randle - Undisclosed, IR. Injured Reserve |
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WR David Bell - Hip, IR. Injured Reserve |
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LB Tony Fields II - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
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DB Myles Harden - Shin, IR. Injured Reserve. Expected Return - Week 6 |
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DB Juan Thornhill - Calf, IR. Injured Reserve. Expected Return - Week 6 |