| LB Boye Mafe - Knee, Full Practice on Wednesday. Questionable for Week 6 vs. San Francisco |
DT Jordan Elliott - Knee, Out for Week 6 at Seattle. Expected Return - Week 7 |
| CB Tariq Woolen - Ankle, Out for Week 6 vs. San Francisco. Expected Return - Week 6 |
SAF Talanoa Hufanga - Wrist, IR. Injured Reserve. Expected Return - Week 11 |
| DT Byron Murphy II - Hamstring, Out for Week 6 vs. San Francisco. Expected Return - Week 6 |
LB Demetrius Flannigan-Fowles - Calf, Out for Week 6 at Seattle. Expected Return - Week 7 |
| LB Uchenna Nwosu - Thigh, Out for Week 6 vs. San Francisco. Expected Return - Week 7 |
K Jake Moody - Ankle, Out for Week 6 at Seattle. Expected Return - Week 8 |
| FS Julian Love - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 vs. San Francisco |
WR Chris Conley - Oblique, Limited Practice on Wednesday. Questionable for Week 6 at Seattle |
| OT Abraham Lucas - Knee, Physically Unable to Perform. Expected Return - Week 6 |
CB Charvarius Ward - Knee, Limited Practice on Wednesday. Questionable for Week 6 at Seattle |
| LB Derick Hall - Foot, Full Practice on Wednesday. Questionable for Week 6 vs. San Francisco |
WR Ricky Pearsall - Chest, NFI-R for Week 6 at Seattle |
| SAF Jerrick Reed II - Knee - ACL, Physically Unable to Perform. Expected Return - Week 6 |
OG Jon Feliciano - Knee, IR. Injured Reserve. Expected Return - Week 6 |
| DT Cameron Young - Knee, Physically Unable to Perform. Expected Return - Week 6 |
CB Ambry Thomas - Forearm, IR. Injured Reserve. Expected Return - Week 6 |
| OT George Fant - Knee, IR. Injured Reserve. Expected Return - Week 7 |
DE Yetur Gross-Matos - Knee, IR. Injured Reserve. Expected Return - Week 10 |
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NT Javon Hargrave - Triceps, IR. Injured Reserve |
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LB Curtis Robinson - Knee - ACL, IR. Injured Reserve |
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LB Dre Greenlaw - Achilles, Physically Unable to Perform. Expected Return - Week 7 |
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RB Christian McCaffrey - Achilles, IR. Injured Reserve. Expected Return - Week 7 |
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RB Elijah Mitchell - Hamstring, IR. Injured Reserve |
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DE Drake Jackson - Knee, Physically Unable to Perform |
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