| MLB Eric Kendricks - Calf, Did Not Practice on Wednesday. Questionable for Week 6 vs. Detroit |
LB Derrick Barnes - Knee, IR. Injured Reserve |
| OLB Nick Vigil - Foot, Did Not Practice on Wednesday. Questionable for Week 6 vs. Detroit |
DE John Cominsky - Knee - MCL, IR. Injured Reserve |
| SAF Markquese Bell - Illness, Did Not Practice on Wednesday. Questionable for Week 6 vs. Detroit |
DT Brodric Martin - Leg, IR. Injured Reserve. Expected Return - Week 6 |
| CB DaRon Bland - Foot, IR. Injured Reserve. Expected Return - Week 6 |
SAF Ifeatu Melifonwu - Ankle, IR. Injured Reserve. Expected Return - Week 9 |
| DE Marshawn Kneeland - Knee - Meniscus, IR. Injured Reserve. Expected Return - Week 11 |
DE Nate Lynn - Shoulder, IR. Injured Reserve |
| LB Micah Parsons - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 vs. Detroit |
K Mike Badgley - Hamstring, IR. Injured Reserve |
| OG Chuma Edoga - Toe, IR. Injured Reserve. Expected Return - Week 6 |
DE Marcus Davenport - Triceps, IR. Injured Reserve |
| WR Brandin Cooks - Knee, IR. Injured Reserve. Expected Return - Week 10 |
OG Christian Mahogany - Illness, NFI-R for Week 6 at Dallas |
| DE DeMarcus Lawrence - Foot, IR. Injured Reserve. Expected Return - Week 10 |
OG Netane Muti - Shoulder, IR. Injured Reserve |
| DT Jordan Phillips - Wrist, IR. Injured Reserve. Expected Return - Week 8 |
DB Emmanuel Moseley - Pectoral, IR. Injured Reserve. Expected Return - Week 6 |
| OT Nathan Thomas - Undisclosed, IR. Injured Reserve |
WR Tre'Quan Smith - Undisclosed, IR. Injured Reserve |
| OT Earl Bostick Jr. - Leg, IR. Injured Reserve |
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| DE Samuel Williams - Knee - ACL, IR. Injured Reserve |
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