| WR Josh Reynolds - Hand, Did Not Practice on Wednesday. Questionable for Week 6 vs. L.A. Chargers |
WR DJ Chark - Hip, IR. Injured Reserve. Expected Return - Week 7 |
| DE John Franklin-Myers - Shoulder, Limited Practice on Wednesday. Questionable for Week 6 vs. L.A. Chargers |
MLB Denzel Perryman - Shoulder, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
| C Luke Wattenberg - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 vs. L.A. Chargers |
RB Gus Edwards - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
| RB Audric Estime - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
CB Asante Samuel Jr. - Shoulder, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
| CB Damarri Mathis - Ankle, IR. Injured Reserve. Expected Return - Week 6 |
K Cameron Dicker - Illness, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
| OT Alex Palczewski - Ankle, Did Not Practice on Wednesday. Questionable for Week 6 vs. L.A. Chargers |
LB Daiyan Henley - Shoulder, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
| SAF Delarrin Turner-Yell - Knee - ACL, Physically Unable to Perform. Expected Return - Week 6 |
CB Kristian Fulton - Knee, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
| RB Tyler Badie - Back, IR. Injured Reserve. Expected Return - Week 9 |
QB Justin Herbert - Ankle, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
| LB Alex Singleton - Knee - ACL, IR. Injured Reserve |
TE Hayden Hurst - Achilles, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
| OT Quinn Bailey - Ankle, IR. Injured Reserve |
CB Ja'Sir Taylor - Leg, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
| LB Baron Browning - Foot, IR. Injured Reserve. Expected Return - Week 7 |
OT Rashawn Slater - Pectoral, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
| OT Mike McGlinchey - Knee - MCL, IR. Injured Reserve. Expected Return - Week 7 |
OT Tyler McLellan - Undisclosed, IR. Injured Reserve |
| LB Drew Sanders - Achilles, Physically Unable to Perform. Expected Return - Week 12 |
LB Joey Bosa - Hip, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
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CB Deane Leonard - Hamstring, Did Not Practice on Wednesday. Questionable for Week 6 at Denver |
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LB Junior Colson - Hamstring, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
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OT Joe Alt - Knee - MCL, Limited Practice on Wednesday. Questionable for Week 6 at Denver |
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LB Nick Niemann - Undisclosed, IR. Injured Reserve. Expected Return - Week 6 |
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LB Chris Rumph II - Foot, IR. Injured Reserve |
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LB Chris Collins - Undisclosed, IR. Injured Reserve |
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C Bucky Williams - Undisclosed, IR. Injured Reserve |
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